Most CFM applications can be grouped into two main categories:

  • Surface analysis and characterization
  • Binding – unbinding events

CFM measurement conditions can be tuned in terms of solvent, temperature and pH. Biological samples can be measured under physiological conditions.


Types of applications:

  • Measurement hydrophilic/hydrophobic interactions
  • Intermolecular force measurements
  • Chemical sensing and detection
  • Local mapping of functional group distributions or receptors
  • Local mapping of surface properties (e.g. modulus)

Application examples in different areas:

  • Polymers (determination composites/blends/phase separation/microstructure)
  • Biomaterials (implants, bio-sensors, dental enamel structure)
  • Tribology (friction, wear)
  • Cosmetics (hair, development shampoos/conditioners, skin, contact lenses)
  • Pharmaceutical industry (study of membrane proteins for development of new drugs)